KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RET
All Species:
8.79
Human Site:
S159
Identified Species:
17.58
UniProt:
P07949
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07949
NP_065681.1
1114
124319
S159
T
S
F
P
A
C
S
S
L
K
P
R
E
L
C
Chimpanzee
Pan troglodytes
XP_001171246
813
90715
Rhesus Macaque
Macaca mulatta
XP_001090823
731
81824
Dog
Lupus familis
XP_543915
1108
124018
S152
T
S
F
P
A
C
G
S
L
K
P
R
E
L
C
Cat
Felis silvestris
Mouse
Mus musculus
P35546
1115
123855
S159
D
T
F
P
N
C
S
S
F
K
A
Q
D
L
C
Rat
Rattus norvegicus
Q04589
822
91806
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507715
665
75620
Chicken
Gallus gallus
P18461
823
92281
Frog
Xenopus laevis
Q03364
813
91322
Zebra Danio
Brachydanio rerio
Q8JG38
817
91370
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09147
1052
117795
T151
L
L
Q
P
L
P
K
T
V
Q
R
T
A
G
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
K76
E
A
I
V
L
T
W
K
K
P
L
K
G
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28.4
27.9
86.4
N.A.
83.4
28.9
N.A.
43
27.5
28.1
27.7
N.A.
23.6
N.A.
N.A.
24
Protein Similarity:
100
42.2
41.5
92
N.A.
90.2
43
N.A.
50.5
43.5
42.3
42
N.A.
37.7
N.A.
N.A.
41.2
P-Site Identity:
100
0
0
93.3
N.A.
53.3
0
N.A.
0
0
0
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
0
0
93.3
N.A.
73.3
0
N.A.
0
0
0
0
N.A.
26.6
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
17
0
0
0
0
0
9
0
9
0
0
% A
% Cys:
0
0
0
0
0
25
0
0
0
0
0
0
0
0
25
% C
% Asp:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% D
% Glu:
9
0
0
0
0
0
0
0
0
0
0
0
17
0
0
% E
% Phe:
0
0
25
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
0
0
0
0
0
9
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
9
9
25
0
9
0
0
0
% K
% Leu:
9
9
0
0
17
0
0
0
17
0
9
0
0
25
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
34
0
9
0
0
0
9
17
0
0
0
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
9
0
9
0
9
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
9
17
0
0
0
% R
% Ser:
0
17
0
0
0
0
17
25
0
0
0
0
0
0
0
% S
% Thr:
17
9
0
0
0
9
0
9
0
0
0
9
0
0
9
% T
% Val:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _